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Bethany van Guelpen

Risk profiling and early detection of colorectal cancer

Colorectal cancer (CRC), the third most common cancer in men and women in Sweden and, if discovered early, prognosis is good. However, despite considerable therapeutic advances in recent decades, the prognosis for advanced CRC is markedly worse. Effective strategies for the prevention and early detection of CRC therefore have great potential to substantially reduce the overall societal burden of this disease.

Colonoscopy is the gold standard for CRC detection. But does everyone really need this uncomfortable and invasive procedure? What if it was possible to use less invasive methods to identify individuals at high risk of developing CRC, or with asymptomatic premalignant or early malignant lesions? Improving risk profiling to allow selection of individuals with the most to win from preventive strategies and colonoscopy screening is a major challenge in CRC research today and the main purpose of Bethany Van Guelpen’s research.

Bethany Van Guelpen’s research has an integrative molecular epidemiology approach, using extensive health and lifestyle data and prospectively collected blood samples from the large, population-based cohorts in northern Sweden, archival tumor tissue from CRC cases in the same cohorts, broad OMICS technologies and advanced statistical analyses.

One main research question, funded by the Swedish Cancer Society (Cancerfonden), is the potentially different role of lifestyle-related factors in subtypes of CRC based on particular traits, or combinations of traits, in the tumor. The lifestyle-related factors include: 1. factors involved in one-carbon metabolism, e.g. plasma folate levels, 2. factors involved in energy metabolism, e.g. body constitution and fasting blood glucose levels, and 3. factors involved in inflammation, e.g. diet and inflammatory markers.

A unique set of longitudinally collected blood samples, taken 10 years apart, in approximately 70 CRC cases and 1:1 time-matched control subjects has also been selected from the same cohorts. Epigenomic, targeted proteomic and metabolomic methods are currently being applied to search for biomarkers of CRC or high CRC risk. Results from the discovery phase will then be validated in larger study sets. The CRC subtype and biomarker results will also be compared and integrated, to provide further etiological insights.

Combining blood-based biomarkers with refined risk profiling for personalized CRC prevention and targeted colonoscopy screening has the potential to reduce CRC incidence and mortality.

To contact Dr van Guelpen, click here

Publikationer

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Stepien, Magdalena
Jenab, Mazda
Freisling, Heinz; et al.

Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
Carcinogenesis, 38(7): 699-707

2017

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Myte, Robin
Gylling, Björn
Häggström, Jenny; et al.

Untangling the role of one-carbon metabolism in colorectal cancer risk: a comprehensive Bayesian network analysis
Scientific Reports, 7

2017

Hämta

Harlid, Sophia
Adgent, Margaret
Jefferson, Wendy N; et al.

Soy Formula and Epigenetic Modifications: Analysis of Vaginal Epithelial Cells from Infant Girls in the IFED Study.
Journal of Environmental Health Perspectives, 125(3): 447-452

2017

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Wilson, Lauren E
Harlid, Sophia
Xu, Zongli; et al.

An epigenome-wide study of body mass index and DNA methylation in blood using participants from the Sister Study cohort
International Journal of Obesity, 41(1): 194-199

2017

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Harlid, Sophia
Myte, Robin
Van Guelpen, Bethany

The metabolic syndrome, inflammation, and colorectal cancer risk: an evaluation of large panels of plasma protein markers using erepeated, prediagnostic samples
Mediators of Inflammation

2017

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Zamora-Ros, Raul
Barupal, Dinesh K.
Rothwell, Joseph A.; et al.

Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort
International Journal of Cancer, 140(8): 1836-1844

2017

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Bodén, Stina
Wennberg, Maria
Van Guelpen, Bethany; et al.

Dietary inflammatory index and risk of first myocardial infarction: a prospective population-based study
Nutrition Journal, 16

2017

Hämta

Nimptsch, Katharina
Song, Mingyang
Aleksandrova, Krasimira; et al.

Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies
European Journal of Epidemiology, 32(5): 419-430

2017

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Moskal, Aurelie
Freisling, Heinz
Byrnes, Graham; et al.

Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study
British Journal of Cancer, 115(11): 1430-1440

2016

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Markunas, Christina A
Wilcox, Allen J
Xu, Zongli; et al.

Maternal Age at Delivery Is Associated with an Epigenetic Signature in Both Newborns and Adults
PLoS ONE, 11(7)

2016

Hämta


Sidansvarig: Maria Wing

Utskriftsversion

Bethany van Guelpen