Molecular epidemiology of brain tumours
The aetiology of brain tumours is largely unknown, and others and we have discovered that there is a familial aggregation of brain tumours.
Our research group is working to discover genes and other etiological factors that are important for the development of brain tumours being co principal investigator for the GLIOGENE consortium including 14 centres internationally.
We also investigate how the aetiological factors relate to the tumour phenotypes leading the brain tumour initiative with Uppsala in the UCAN consortium.
To explore novel genes and biomarkers associated with different brain tumours and other tumour types we work as coordinator for brain tumours in the prospectively collected cohort, Northern Sweden Health and disease study including more than 100 000 unique individuals
The research group is also working on studies in other tumor areas such as colorectal cancer, lymphoma and breast cancer, especially regarding hereditary cancer and biomarkers for etiology and early detection
Melin works as the National coordinator of the cancer strategy in Sweden and the chair of Regional Cancer Centers in cooperation, supporting the development and improvement of cancer care in Sweden.
Members of the research group:
Beatrice Melin, Professor Head Regional Cancer center, Senior consultant in Oncology
Ulrika Andersson, Research coordinator
Carl Wibom, Assistant Professor Bioinformatic profile
Anna Dahlin, Post doc Bioinformatic profile
Benny Björkblom, Post doc Metabolomics project
Barbro Numan, Post doc, Statistician
Karin Papworth, Post doc Clinical oncologist
Sara Huggert, Research assistant
Mikael Kimdahl, Lab technician
Sara Sjöström, Post doc Clinical Oncologist
Sonia Katsuura, Data base manager
Ulf Hjalmars, Pediatric Oncologist
Florentin Späth, PhD student
Lena Brandefors, PhD student
Olof Sjöström, Phd student
Christina Ardnor- Edvinsdotter, PhD student
Gustav Silander, PhD student
To contact prof Beatrice Melin, click here.
Examples of publications (Malmer until 2010, after 2010 Melin)
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
Nat Genet. 2017 Mar 27. doi: 10.1038/ng.3823
Melin B et al
Metabolomic screening of pre-diagnostic serum samples identifies association between α- and γ-tocopherols and glioblastoma risk
Oncotarget. 2016 Jun 14;7(24):37043-37053. doi: 10.18632/oncotarget.9242.
Björkblom B, Wibom C, Jonsson P, Mörén L, Andersson U, Johannesen TB, Langseth H, Antti H, Melin B.
Cancer Epidemiol Biomarkers Prev. 2015 May;24(5):810-6. doi: 10.1158/1055-9965.EPI-14-1106. Epub 2015 Feb 20.Investigation of established genetic risk variants for glioma in prediagnostic samples from a population-based nested case-control study.
Wibom C, Späth F, Dahlin AM, Langseth H, Hovig E, Rajaraman P, Johannesen TB, Andersson U, Melin B.
Germline mutations in shelterin complex genes are associated with familial glioma.
Bainbridge MN, Armstrong GN, Gramatges MM, Bertuch AA, Jhangiani SN, Doddapaneni H, Lewis L, Tombrello J, Tsavachidis S, Liu Y, Jalali A, Plon SE, Lau CC, Parsons DW, Claus EB, Barnholtz-Sloan J, Il'yasova D, Schildkraut J, Ali-Osman F, Sadetzki S, Johansen C, Houlston RS, Jenkins RB, Lachance D, Olson SH, Bernstein JL, Merrell RT, Wrensch MR, Walsh KM, Davis FG, Lai R, Shete S, Aldape K, Amos CI, Thompson PA, Muzny DM, Gibbs RA, Melin BS, Bondy ML; Gliogene Consortium. J Natl Cancer Inst. 2014 Dec 7;107(1):384. doi: 10.1093/jnci/dju384. Print 2015 Jan
Genome-wide association study identifies five susceptibility loci for glioma.
Shete S, Hosking FJ, Robertson LB, Dobbins SE, Sanson M, Malmer B, Simon M, Marie Y, Boisselier B, Delattre JY, Hoang-Xuan K, El Hallani S, Idbaih A, Zelenika D, Andersson U, Henriksson R, Bergenheim AT, Feychting M, Lönn S, Ahlbom A, Schramm J, Linnebank M, Hemminki K, Kumar R, Hepworth SJ, Price A, Armstrong G, Liu Y, Gu X, Yu R, Lau C, Schoemaker M, Muir K, Swerdlow A, Lathrop M, Bondy M, Houlston RS. Nat Genet. 2009 Aug;41(8):899-904. doi: 10.1038/ng.407. Epub 2009 Jul 5.
GLIOGENE an International Consortium to Understand Familial Glioma.
Malmer B, Adatto P, Armstrong G, Barnholtz-Sloan J, Bernstein JL, Claus E, Davis F, Houlston R, Il'yasova D, Jenkins R, Johansen C, Lai R, Lau C, McCarthy B, Nielsen H, Olson SH, Sadetzki S, Shete S, Wiklund F, Wrensch M, Yang P, Bondy M. Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1730-4. Review.